If the USB to UART adapter you are using for serial communication between your Pi Pico board and your PC has a DTR output, connect it to the RUN pin (pin 30) of the Pi Pico:
https://www.raspberrypi.com/documentati ... eries.html
You can then conveniently Reset the Pi Pico by clicking on the Reset button of the Astrobe Terminal:
Reset the Pi Pico from the Astrobe Terminal
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